Posted on : Thursday 22 February 2018

Job title : 2018/02/22 – Postdoctoral position: “Organic chemistry and radiochemistry” (1 year)

Organization : The IMIV laboratory (Imagerie Moléculaire In Vivo) located at the Service Hospitalier Frédéric Joliot (Orsay, France) is a multidisciplinary infra-structure gathering all activities from organic chemistry to clinical trials including preclinical imaging and signal quantification. The laboratory is fully equipped for radiochemistry with positrons emitters such as fluorine-18, carbon-11 and zirconium-89.
The Service de Chimie Bioorganique et de Marquage (SCBM located at Saclay, CEA) conducts methodological research in organic, bioorganic and macrocyclic chemistry, develops targeted drugs and inhibitors in collaboration with biologists.
The work of the postdoctoral fellow will be shared between these two laboratories (IMIV and SCBM) that are only distant of a few kilometers.

Mission : Applicants are invited to apply for a postdoctoral researcher position in organic chemistry and radiochemistry funded by the Agence Nationale de la Recherche (ANR).
Combined [18F]PET/NIRF imaging (Positron Emission Tomography/Near Infra Red Fluorescence) hold a huge potential to transform patient diagnosis and care. Such a combination conjugates the non-invasive whole-body diagnosis of PET with the intraoperative imaging-guided surgery or ex vivo histopathology of NIRF imaging. To implement this highly valuable dual imaging theranostic approach, adapted and smart imaging tools have to be developed. In the frame of the M3ODALIty project funded by the Agence Nationale de la Recherche (ANR), new monomolecular, multivalent and multiplexed PET/NIRF imaging agents will be synthesized.
The objectives are:
- To synthesize a series of dual PET/NIRF probes bearing a fluorine-18 atom,
- To functionalize bambusuril-based scaffolds with in vivo targeting entities and the dual imaging dye to build new imaging agents that can be used in combined PET and NIRF imaging.
The laboratories involved in M3ODALIty are located at the CEA-Saclay and Orsay (around 20 km south of Paris).
Availability:
June/September 2018,

Locality : IMIV (CEA-SHFJ, Orsay) and SCBM (CEA, Saclay) (around 20 km south of Paris)

Remuneration : around 2200 €/month

Degrees required : PhD in organic chemistry with a strong organic synthesis background

Skills required : Experience in fluorescent dye synthesis or macrocyclic chemistry would be appreciated.

Contact : Applicants are invited to send a CV, cover-letter, list of publications and references to: Bertrand Kuhnast, bertrand.kuhnast@cea.fr and Marie Pierre Heck, marie-pierre.heck@cea.fr